U S E-cigarette Sales Climbed Throughout 2020-2022 Cdc On-line Newsroom Given that nicotine easily diffuses from the dermis to the bloodstream, acute nicotine exposure by e-liquid spilling (5 mL of a 20 mg/mL nicotine-containing refill is equivalent to 100 mg of nicotine) can easily be poisonous or even deadly . Thus, units with rechargeable refills are another problem of concern with...